Serine Racemase (SR)

Serine Racemase; SR

Serine Racemase converts L-serine into D-serine, which acts as an agonist of the NMDA receptor, regulates the neuronal excitability, synaptic transmission, and is involved in neuroprotective mechanisms. Serine Racemase is mainly located in the cytoplasm of neurons, especially in the synaptic region. Serine Racemase dysfunction could lead to neurological diseases, such as ischemic stroke and schizophrenia^[1].

References:

[1]. Graham DL, et al., Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function. Front Mol Biosci. 2019 Mar 13;6:8. [Content Brief]

Serine Racemase (SR) Inhibitor (1)

Serine Racemase (SR) Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-162652

HSR-IN-1	Inhibitor
HSR-IN-1 (Compound 28) is an effective hSR (human serine racemase) inhibitor. In the presence of the cofactor Pyridoxal 5'-phosphate monohydrate (HY-W011727A), HSR-IN-1 has a K_d value of 5.4 μM and an IC₅₀ of 18.3 μM for hSR, while the IC₅₀ of HSR-IN-1 alone is 4.7 μM. HSR-IN-1 can be used for research on central nervous system diseases.

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